[The effect of thalicoside on reproductive function in an experiment]. / Vliianie talikozida na reproduktivnuiu funktsiiu v éksperimente.

Talicoside, a triterpene glycoside from Thalictrum minus L., given in an oral dose og 1 mg/kg for 5 days was demonstrated to cause ovulation stimulation induced by intravenously injecting 1.2% solution of copper acetate into the rabbits. The agent enterally administered in a dose of 1 mg/kg to rats for 5 days reduced the levels of luteinizing hormone and elevated serum follicle-stimulating hormone in proestrous and estrous.

[An experimental study of sulprostone as an agent in preparation for abortion]. / Eksperimental'noe issledovanie sul'prostona kak sredstva podgotovki k abortu.

The prostaglandin E sulprostone was studied in experiments on pregnant rats. It was shown to stimulate the bioelectrical activity of the uterus, by increasing the amplitude and frequency of biological potentials. Sulprostone was found to have abortive and embryotoxic effects which were especially pronounced during placentation. The drug induced a slight teratogenic effect.

[The clinico-pharmacological characteristics of anteovin]. / Kliniko-farmakologicheskaia kharakteristika anteovina.

The clinical and laboratory studies carried out on 160 women showed a high contraceptive effect and good tolerance of anteovine. The contraceptive effect of the biphasic drug is determined by its antiovulatory action concurrent with inhibition of the basal periovulatory secretion of gonadotropins and secretion of sex hormones.

PIP: The results of evaluation of the contraceptive activity of the biphasic oral contraceptive anteovin are presented. 1 package of anteovin consists of 11 white tablets containing 0.05 mg of ethinyl estradiol and 0.05 mg of levonorgestrel and 10 pink tablets of 0.05 mg of ethinyl estradiol and 0.125 mg of levonorgestrel. Anteovin was tested according to the conventional 21-day regimen from day 5 of the cycle for 21 days, followed by 1 7-day rest period. Duration of anteovin administration ranged from 1 to 12 cycles. Anteovin was given to 160 women (aged 17 to 40 years old) who had a history of 618 pregnancies (182 ended by term delivery and 436 ended by induced abortion). During anteovin administration none of the women became pregnant. Side effects of anteovin included mild nausea during first several days in 12 women, breast tenderness in 4, and menstruation disorders in 8. The mechanism of contraceptive effect of anteovin was associated with ovulation inhibition. The changes in the basal temperature had a monophasic characteristic. Colpocytological examination showed decrease in the karyopyknotic and eosinophilic indices to 4-30%. All estrogen fractions (estrone, estradiol and estriol) in the urine showed statistically significant decrease on day 14-16 of the cycle (to 15.8 mcg/day, compared with 41.9 mcg/day in controls). The level of pregnanediol in the urine showed a decrease on day 20-23 of the cycle (0.66 mg/day, compared with 2.98 mg/day in controls). After 6 months of anteovin administration, there was a decrease in the basal and periovulation secretion of follicle-stimulating hormone, luteinizing hormone, and estradiol.

[Acetomepregenol in the treatment of threatened late miscarriages (clinico-experimental study)]. / Atsetomepregenol v lechenii ugrozaiushchikh pozdnykh vykidyshei (kliniko-éksperimental'noe issledovanie).

A new Soviet synthetic gestagen, acetomepregenol, was used to control threatened abortion in 46 patients, aged 20 to 40 years. The use of acetomepregenol was shown to be justified as part of combined treatment in cases where the cause of threatened abortion is depressed ovarian activity.

[Protective action of estrogen-progestin preparations in reproductive function disorder from subtoxic doses of organophosphorus compounds]. / Zashchitnoe deistvie éstrogen-progestinovykh preparatov pri narushenii reproduktivnoi funktsii subtoksicheskimi dozami fosfororganicheskikh soedinenii.

The action of subtoxic doses of armine and nibufin administered alone and combined with steroid drugs on the rat reproductive function and uterine tissue RNA content was studied experimentally. The subtoxic doses of the drugs increased sharply the luteinizing hormone releasing factor content in the hypothalamus, as well as the synthesis and excretion of luteinizing and follicle-stimulating hormones and RNA content in the uterine tissue. Estrogen-progestin drugs, particularly infecundin, exerted a protective action in armine- and nibufin-produced abnormalities of the reproductive function.

[The effect of nibufin on reproductive function and the contraceptive effect of hormonal preparations]. / Vliianie nibufina na reproduktivnuiu funktsiiu i kontratseptivnyi effekt gormonal'nykh preparatov.

PIP: 215 pubescent female rats were administered with nibufine in 3 series; over a 10-day period with a daily dose of .8 mg/kg, over a 14-day period with a daily dose of .8 mg/kg together with 1.5 mg/kg of megestranol, and with a dose of .8 mg/kg together with cholinesterase, amizile (10 mg/kg), or spazmolitine (30 mg/kg). Nibufine inhibited the activity of cholinesterase in the blood, disturbed the reproductive function, and strengthened the depressive effects on reproduction of the synthetic oral contraceptives megestranol and particularly infecundin. The ill effects of nibufine of the reproductive function were significantly reduced under the influence of amizile. The effects of spazmolitine was less pronounced.^ieng